SBA 504 Life Science Lab Feasibility Study

The national SBA 504 record for life science lab (research and development) projects, from SBA's loan-level files, and what a lender's feasibility study has to test.

Research firms buying lab buildings

SBA's 504 record holds 48 life science lab loans approved over FY2017 to FY2026, $72.3 million of gross dollars. The class is defined by the research business rather than the building, and its code also takes in research firms outside the life sciences, so these are loans to companies that do research, some of which bought or built space to do it in. The median is what marks the cell out. At $1.0 million, the median 504 lab loan sits far above the two-program median for research firms, a level that small 7(a) research loans set, and it also differs, on our test, from what 504 lends across all of its classes. Half of the 504 lab loans run from $498,750 to $2.2 million.

A California-centered book with many cancellations

California accounts for 21 of the 48 loans; Florida and Massachusetts have 4 each, and Colorado, Georgia, Michigan, Nevada and Ohio 2 apiece. The Mortgage Capital Development Corporation holds 12 lab loans worth $26.3 million and California Statewide Certified Development Corporation 6 worth $13.6 million. Cancellation is the warning in this record. Lab approvals of FY2017 through FY2024 cancelled at a floor of 20.0%, and at 25.0% once every lab approval not yet disbursed is treated as lost. We withhold the charge-off rate, because fewer than 30 research firm loans sit in the funded cohort, so the page offers no loss figure at all. The franchise share is 0.00%. FY2022 brought 10 loans and $17.1 million; FY2026 brought none.

Underwriting a lab under 504

A 504 lab project asks a lender to believe in two things at once: the research company's revenue, and a specialized building's value. A feasibility study has to test both. On the business side, it should look at grant and contract revenue, how long the current funding runs, customer concentration, and whether revenue depends on a single study, client or principal investigator. On the property side, cost has to cover laboratory fit-out, ventilation and fume handling, power, vibration control and any clean room, since lab space costs far more to build than office space. Coverage on the bank loan and the CDC debenture should hold if a contract ends early. The appraisal is the difficult part: a lab building has a small buyer pool outside the strongest research markets, so the study should state what the building is worth to another research tenant and what it would be worth converted to ordinary office or flex use.

SBA 504 life science lab (research and development) loans in the United States

Loans approved, FY2017 to FY202648
Gross dollars approved$72.3 million
Median loan$1.0 million
Middle half of loans, from$498,750
Middle half of loans, to$2.2 million
Franchise share of loans0.00%

Cancellation and charge-off

Cancelled after approval, FY2017 to FY2024 approvals (a floor) 20.0%
The same, counting loans still undisbursed as cancelled (a ceiling)25.0%
Charged off to date, FY2017 to FY2021 disbursed loans (a floor) not reported: fewer than 30 loans in the cohort

Both rates are floors. SBA withholds the status of open loans, so a loan counts as charged off only once SBA reports it; a rate needs at least 30 loans in its cohort and is otherwise not reported.

SBA 504 life science lab (research and development) loans approved in the United States, by fiscal year

0246810FY2017FY2018FY2019FY2020FY2021FY2022FY2023FY2024FY2025FY2026Loans, FY2017: 1Loans, FY2018: 3Loans, FY2019: 1Loans, FY2020: 6Loans, FY2021: 8Loans, FY2022: 10Loans, FY2023: 3Loans, FY2024: 8Loans, FY2025: 8Loans, FY2026: 0
Fiscal yearLoansDollars
FY20171$394,000
FY20183$5.2 million
FY20191$155,000
FY20206$10.1 million
FY20218$9.1 million
FY202210$17.1 million
FY20233$6.1 million
FY20248$15.9 million
FY20258$8.3 million
FY20260$0

Most active SBA lenders

SBA 504: lenders by loans approved (the current holder of each loan, as SBA reports it)
LenderLoansDollars
The Mortgage Capital Development Corporation12$26.3 million
California Statewide Certified Development Corporation6$13.6 million

Where the loans are, by state

StateLoans
California21
Florida4
Massachusetts4
Colorado2
Georgia2
Michigan2
Nevada2
Ohio2
Alabama1
Illinois1

The code is the research business, not the lab building; 541715 also holds non-life-science research.

Source: U.S. Small Business Administration, 7(a) and 504 loan-level FOIA files (data.sba.gov), as of 2026-09-30; Loan Analytics loan-outcome cell PA-C26-504.

Loan Analytics prepares the feasibility study a lender reads before it commits: for a life science lab (research and development) project anywhere in the United States, financed under SBA 7(a), SBA 504, USDA Business and Industry or a conventional bank loan. Tell us the project and the lender's deadline, and we reply with scope, timeline and fee.

Request Scope & Timeline

Start with the data.

Contact Us