SBA 504 Life Science Lab Feasibility Study
The national SBA 504 record for life science lab (research and development) projects, from SBA's loan-level files, and what a lender's feasibility study has to test.
Research firms buying lab buildings
SBA's 504 record holds 48 life science lab loans approved over FY2017 to FY2026, $72.3 million of gross dollars. The class is defined by the research business rather than the building, and its code also takes in research firms outside the life sciences, so these are loans to companies that do research, some of which bought or built space to do it in. The median is what marks the cell out. At $1.0 million, the median 504 lab loan sits far above the two-program median for research firms, a level that small 7(a) research loans set, and it also differs, on our test, from what 504 lends across all of its classes. Half of the 504 lab loans run from $498,750 to $2.2 million.
A California-centered book with many cancellations
California accounts for 21 of the 48 loans; Florida and Massachusetts have 4 each, and Colorado, Georgia, Michigan, Nevada and Ohio 2 apiece. The Mortgage Capital Development Corporation holds 12 lab loans worth $26.3 million and California Statewide Certified Development Corporation 6 worth $13.6 million. Cancellation is the warning in this record. Lab approvals of FY2017 through FY2024 cancelled at a floor of 20.0%, and at 25.0% once every lab approval not yet disbursed is treated as lost. We withhold the charge-off rate, because fewer than 30 research firm loans sit in the funded cohort, so the page offers no loss figure at all. The franchise share is 0.00%. FY2022 brought 10 loans and $17.1 million; FY2026 brought none.
Underwriting a lab under 504
A 504 lab project asks a lender to believe in two things at once: the research company's revenue, and a specialized building's value. A feasibility study has to test both. On the business side, it should look at grant and contract revenue, how long the current funding runs, customer concentration, and whether revenue depends on a single study, client or principal investigator. On the property side, cost has to cover laboratory fit-out, ventilation and fume handling, power, vibration control and any clean room, since lab space costs far more to build than office space. Coverage on the bank loan and the CDC debenture should hold if a contract ends early. The appraisal is the difficult part: a lab building has a small buyer pool outside the strongest research markets, so the study should state what the building is worth to another research tenant and what it would be worth converted to ordinary office or flex use.
SBA 504 life science lab (research and development) loans in the United States
| Loans approved, FY2017 to FY2026 | 48 |
|---|---|
| Gross dollars approved | $72.3 million |
| Median loan | $1.0 million |
| Middle half of loans, from | $498,750 |
| Middle half of loans, to | $2.2 million |
| Franchise share of loans | 0.00% |
Cancellation and charge-off
| Cancelled after approval, FY2017 to FY2024 approvals (a floor) | 20.0% |
|---|---|
| The same, counting loans still undisbursed as cancelled (a ceiling) | 25.0% |
| Charged off to date, FY2017 to FY2021 disbursed loans (a floor) | not reported: fewer than 30 loans in the cohort |
Both rates are floors. SBA withholds the status of open loans, so a loan counts as charged off only once SBA reports it; a rate needs at least 30 loans in its cohort and is otherwise not reported.
SBA 504 life science lab (research and development) loans approved in the United States, by fiscal year
| Fiscal year | Loans | Dollars |
|---|---|---|
| FY2017 | 1 | $394,000 |
| FY2018 | 3 | $5.2 million |
| FY2019 | 1 | $155,000 |
| FY2020 | 6 | $10.1 million |
| FY2021 | 8 | $9.1 million |
| FY2022 | 10 | $17.1 million |
| FY2023 | 3 | $6.1 million |
| FY2024 | 8 | $15.9 million |
| FY2025 | 8 | $8.3 million |
| FY2026 | 0 | $0 |
Most active SBA lenders
| Lender | Loans | Dollars |
|---|---|---|
| The Mortgage Capital Development Corporation | 12 | $26.3 million |
| California Statewide Certified Development Corporation | 6 | $13.6 million |
Where the loans are, by state
| State | Loans |
|---|---|
| California | 21 |
| Florida | 4 |
| Massachusetts | 4 |
| Colorado | 2 |
| Georgia | 2 |
| Michigan | 2 |
| Nevada | 2 |
| Ohio | 2 |
| Alabama | 1 |
| Illinois | 1 |
The code is the research business, not the lab building; 541715 also holds non-life-science research.
Source: U.S. Small Business Administration, 7(a) and 504 loan-level FOIA files (data.sba.gov), as of 2026-09-30; Loan Analytics loan-outcome cell PA-C26-504.
Related feasibility study pages
- Feasibility studies for life science lab projects
- SBA loan data for feasibility studies by asset class
- SBA 7(a) Life Science Lab Feasibility Study
- SBA feasibility study company
- SBA 504 Restaurant Feasibility Study
- SBA 504 Hotel Feasibility Study
- SBA 504 Child Care Center Feasibility Study
- SBA 504 Quick Service Restaurant Feasibility Study
- SBA 504 Auto Repair Shop Feasibility Study
- SBA 504 Medical Office Feasibility Study
- SBA 504 Dental Office Feasibility Study
- SBA 504 Car Wash Feasibility Study
Loan Analytics prepares the feasibility study a lender reads before it commits: for a life science lab (research and development) project anywhere in the United States, financed under SBA 7(a), SBA 504, USDA Business and Industry or a conventional bank loan. Tell us the project and the lender's deadline, and we reply with scope, timeline and fee.
Request Scope & Timeline
Start with the data.
Contact Us